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How Heliprobe Works |
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| A.) |
On an empty
stomach the patient swallows a HeliCap™ Capsule
with a glass of water. |
| B.) |
HeliCap™, containing
1 C-labeled urea, disintegrates rapidly in the stomach
and the 1 C-urea is dissolved. |
| C.) |
In the presence of Helicobacter
pylori, the 1 C-urea is metabolized to carbon dioxide
and ammonia by the enzyme urease, produced by Helicobacter
pylori. |
| D.) |
The available 14C
isotopes, now in the form of 14CO2,
diffuse into the blood to be transported to the
lungs, where it is exhaled in the breath to be captured
during sampling. A positive answer offers conclusive
evidence that the patient is infected with Helicobacter
pylori. |
| E.) |
In the absence of Helicobacter
pylori, the administered urea is absorbed in the
gastrointestinal tract and subsequently voided. |
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| Validation Of The
Method |
| The Heliprobe™ system has
been validated and found to be comparable to conventional
UBT, with the advantage of being a diagnostic system for
detection of H. pylori directly in the doctor’s
office. Results are expressed as 0= patient not infected,
2= patient infected, 1= borderline. |
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